PLA2R1 and autoimmune disease: MGN pathogenesis involves the formation of immunocomplexes in subepithelial region and it is considered an autoimmune disease limited to the kidney as the immunocomplex formation is due to immunoglobulin binding to podocytary antigen PLA2R in situ, which leads to activation of complement system, causing podocytary injury and consequently NS and renal failure13.