AGER and Familial prostate cancer: Several reports had revealed an association between the expression of RAGE and development of cancers, as Aboushousha et al., (2016) found that RAGE expression was up-regulated in human gastric adenocarcinoma and Kuniyasu et al., (2003) described that RAGE production was enhanced in metastatic compared to non-metastatic prostate cancer and healthy prostate tissue.