SOX2 functions as an oncoprotein and promotes cancer progression and focused on its positive contribution to many physiological processes of cancer cells, such as proliferation and growth, cellular migration and invasion, maintenance of stemness, anti-apoptotic activity, chemoresistance, metastasis and tumorigenesis, however, the mechanisms involved remain largely unknown, both in prostate and in other cancers (Weina and Utikal, 2014). The gene discussed is SOX2; the disease is cancer.