In our study, we found significant increase in mean percentage of RAGE positive cells in prostate cancer tissue compared with prostatitis and BPH, which matches results of Lu et al., (2010) who reported a significant higher expression of RAGE in the prostate cancer than in normal prostate tissue by immunohistochemistry, western blot analysis and real-time quantitative PCR. Here, AGER is linked to benign prostatic hyperplasia.