In another study, mouse hepatoma cells treated with 30% ethanol extracts of CN in low or high doses showed a significant decrease in the expression of PCNA and p-AKT (proliferation markers) and increased expression of BAX, Bcl2, caspase-3, and PAPR (apoptosis markers) (Huang et al., 2015). This evidence concerns the gene CASP3 and hepatocellular carcinoma.