About 90% of breast cancer patients die from tumor metastasis.2 In the development of breast cancer, the estrogen receptor (ER)‐mediated signaling pathway is an important factor regulating the proliferation and migration of breast cancer cells.3 Therefore, exploring the mechanism of the ER signaling pathway and exploring drugs that target the ER signaling pathway are important strategies for the treatment of breast cancer. This evidence concerns the gene ESR1 and neoplasm.