2009), and the authors reported that expression of miR‐1 and miR‐133 were significantly increased in heart failure, while expression of PP2A catalytic and regulatory subunits (putative targets of miR‐133 and miR‐1) were decreased (Belevych et al. 2011). Moreover, the decreased PP2A activity observed in heart failure was accompanied by enhanced CaMKII‐mediated phosphorylation of RyR2 at Ser‐2814, and increased frequency of diastolic calcium waves and after‐depolarizations, in heart failure rats compared with controls (Terentyev et al. 2009). The gene discussed is RYR2; the disease is heart failure.