SLC17A6 and substance dependence: Hence, to further understanding of the role of VGLUT2, and specifically of the rs2290045 genotype, in alcohol misuse, the present study sought to determine whether alcohol-related problems (i.e. hazardous alcohol use, dependence symptoms and harmful alcohol use [5]) were associated with interactions of VGLUT2 SNP rs2290045 and positive and negative environmental factors.