CCL2 and retinal degeneration: The preclinical study supporting its development was performed in a retinal degeneration mouse model of advanced AMD having a mutation in either monocyte chemoattractant protein 1 (MCP-1 or CCL-2) or its cognate receptor (chemokine receptor 2, CCR2) and presenting with drusen below the RPE, accumulation of lipofuscin in RPE, photoreceptor atrophy, and CNV.