The t(8;21) is one of the most frequent chromosomal translocations in acute myeloid leukemia and encodes a fusion protein containing the DNA binding domain of RUNX1 linked to the majority of the myeloid translocation gene on chromosome 8 (MTG8, also known as eight-twenty-one or ETO; gene name RUNX1T1). Here, RUNX1 is linked to acute myeloid leukemia.