The only previous correlation study showed that the T allele of rs5435 was associated with a high risk of T2DM [26]. SLC2A4 rs5435, a tagSNP, is located in the coding region, and the mutation is a synonymous mutation. SLC2A4 rs5435 may affect glucose metabolism in pregnant women by influencing the level of mRNA and further modulating the protein level of SLC2A4, thus leading to a high risk of GDM [7]. The gene discussed is SLC2A4; the disease is type 2 diabetes mellitus.