Compared to pregnant women with the other genotype combinations, pregnant women with SLC2A4 rs5435 (CC/CT), RBP4 rs7091052 (CC), PCK1 rs1042531 (TT/TG) and rs2236745 (TT), and PIK3R1 rs34309 (AA) had a lower GDM risk (OR=0.231, p=0.012). The gene discussed is PIK3R1; the disease is gestational diabetes.