One of the early studies in patients with relapsed acute myeloid leukemia, showed haploidentical NK cell infusion in combination with high dose fludarbine and cyclophosphamide caused expansion of donor NK cells, significantly increased endogenous Interleukin (IL)-15 and achieved a complete hematologic remission in 5 of 19 (26%) patients (1). This evidence concerns the gene IL15 and acute myeloid leukemia.