Both matrices are derived from Engelbreth-Holm-Swarm mouse sarcoma, and contain growth factors (EGF, FGF, TGFβ, IGF) (81), ECM proteins (laminin, collagen IV, entactin) (82), proteases (MMP-2, MMP-9) (83), and perlecan (84). This evidence concerns the gene HSPG2 and sarcoma.