In this context, higher levels of circulating MACC1 mRNA, peripheral soluble or tumor lesion protein expression was significantly associated with poor survival in patients such as lung cancer (22, 23), gastric cancer (24), glioma (25), cervical cancer (26), hepatocellular, and renal pelvis carcinoma (12, 27). This evidence concerns the gene MACC1 and renal pelvis carcinoma.