In this context, higher levels of circulating MACC1 mRNA, peripheral soluble or tumor lesion protein expression was significantly associated with poor survival in patients such as lung cancer (22, 23), gastric cancer (24), glioma (25), cervical cancer (26), hepatocellular, and renal pelvis carcinoma (12, 27). The gene discussed is MACC1; the disease is cervical carcinoma.