Similar to these findings, previous studies also indicated that α-lipoic acid strongly reversed oxidative stress by directly or indirectly reacting to ROS in various disease models related to oxidative stress such as neurodegeneration, diabetes mellitus, and ischemic injury [19], and that the ROS scavenger effectively blocked NRLP3 activation, NF-κB nuclear translocation, and downstream inflammatory cytokine expression [36, 37]. This evidence concerns the gene NFKB1 and diabetes mellitus.