Additionally, with recent findings that somatic FBXL4 mutations increase the likelihood of prostate cancer metastasis to bone (Stankiewicz et al., 2017), and modify the circadian GABA-ergic cyclical alteration in lateral ventral nuclei of drosophila (Li et al., 2017), suggest not only a potential role for FBXL4 in cell migration, but possibly in the sleep-wake cycle as well, respectively. This evidence concerns the gene FBXL4 and prostate carcinoma.