IFNG and neoplasm: It has been shown that the Th1-cytokine IFN-γ activates HIF-1α leading to increased iNOS expression (31) and that myeloid cells acquire suppressive activity under hypoxic tumor conditions that can be abrogated by inhibiton of iNOS (23) so that it could be speculated that decreased generation of NO in HIF-KO MDSC leads to their decreased suppressive activity.