TNF and Sepsis: In accordance with organ dysfunction in the FtHfl/fl mice, 24 h after CLP surgery, there was a significant increase in the levels of cytokines that have been implicated in the pathogenesis of sepsis, including the pro-inflammatory cytokines, TNF-α, IFN-γ, IL-6, IL-12, CXCL1, IL-1β, and IL-2 (Figure 2).