Other CARs mentioned in this review that use the CD28ζ costimulatory domain include L1CAM CARs for ovarian cancer in mice (45), MET CARs for MPM (48), MUC16 CARs in mouse models of ovarian cancer and peritoneal carcinomatosis (53, 67), and NKG2D CARs in Ewing's sarcoma models (54). This evidence concerns the gene MUC16 and ovarian cancer.