ERBB2 and neoplasm: Other 4-1BB based CARs from in vivo studies described in this review include HER2 CARs in models of medulloblastoma and gastric cancer (92,30); GD2 CARs in models of neuroblastoma and patients with melanoma (29, 30); mesothelin CARs in preclinical models of mesothelioma (64); and FAP CARs used in models of tumor associated stroma (102).