In contrast, previous reports using c-fos deficient osteopetrotic mice crossed with TNF arthritic mice demonstrated that osteopetrosis is dispensable for TNF-mediated arthritis as synovial inflammation was not affected whereas bone resorption was blocked (40), supporting RANKL involvement in arthritis as shown in Tg197/Rankltles/tles mice. This evidence concerns the gene TNFSF11 and arthritic joint disease.