Histopathological analysis at 6 weeks of age, when arthritic manifestations in Tg197 mice were restricted on synovial hyperplasia and focal pannus formation, showed significantly increased arthritis progression in Tg197/Tg5519 mice characterized by aggravated inflammatory pannus formation, increased osteoclastogenesis, massive bone destruction and surface cartilage degradation as indicated by staining with hematoxylin/eosin, TRAP and Toluidine blue (Figures 2C,D). The gene discussed is ACP5; the disease is Arthritis.