Simultaneous overexpression of RANKL and TNF in Tg197/TgRANKL mice resulted in an aggressive arthritic phenotype, characterized by earlier arthritis onset and exacerbated clinical symptoms, such as reduced body weight gain and increased arthritis scores compared to Tg197 arthritic control mice (Figures 2A,B). Here, TNFSF11 is linked to arthritic joint disease.