ACAP2 (ArfGAP With Coiled-Coil, Ankyrin Repeat And PH Domains 2), is a GTPase-activating protein that plays central role in endocytosis and FcγR-mediated phagocytosis (77), while CRP2 (Cysteine Rich Protein 2) is a new cytoskeletal component of invadopodia promoting breast cancer cell invasiveness and metastasis (78). The gene discussed is CRIP2; the disease is breast carcinoma.