HNRNPM and breast carcinoma: Moreover, HNRNPM (Heterogeneous nuclear ribonucleoprotein M), a component of the spliceosome machinery, promotes alternative spicing, cell proliferation and progression of breast cancer (67), while SRRT (Serrate, RNA Effector Molecule) participates to mRNA splicing and primary miRNA processing (68), it is involved in cell cycle progression at S phase, and its genetic deletion resulted in defective hematopoiesis in bone marrow and thymus (69).