Similarly, previous reports have shown that induction of K/BxN serum transfer arthritis in RANK-deleted mice, resulted in osteoclastogenesis in the inflamed synovium but not in the bone marrow, supporting RANKL-indepedent mechanisms for osteoclast formation in vivo in a sufficiently inflamed environment (43). The gene discussed is TNFSF11; the disease is arthritic joint disease.