CXCR2 and chronic obstructive pulmonary disease: Selective anti-CXCR2 blockade using AZD5069 limited NET formation in autologous blood and sputum neutrophils derived from the same COPD patients ex vivo (30), representing the first reported evidence that a CXCR2 antagonist can stabilize COPD-derived NET formation (Figures 1B–D).