This adverse event was not mentioned in the publication of the results and this vorapaxar-ALS association may recall the studies we and others carried out with thrombin, PAR1, thrombospondin, TM and related components of the coag-inflamm system in development, neurotrauma, ALS and other neurodegenerative disorders, as described above (see Table 1). Here, F2R is linked to amyotrophic lateral sclerosis.