The correlation of serum and CSF KNG levels was higher in patients with encephalitis (Pearson coefficient 0.562, p = 0.057) than in controls (Pearson coefficient 0.138, p = 0.825), but both failed to showed significance (Figures 3C,D), suggesting that the upregulated KNG level in the CSF was not likely due to increased synthesis in peripheral tissues, in accordance with the finding in the study on rats. This evidence concerns the gene KNG1 and encephalitis.