There was a significant decrease in blood lipids, and a marked improvement in surrogate markers of insulin secretion (HOMA-B, calculated as described in Levy et al., 1998); or IS (HOMA of insulin resistance, HOMA-IR, HOMA-S, Disse index, the quantitative IS check index, QUICKI, the revised QUICKI, insulin to glucose ratio, and the new FIRI, Table 1). Here, INS is linked to Insulin resistance.