Consequently, active PKC isoforms may contribute to hyperglycemia-induced vascular endothelial damage by inhibiting insulin-stimulated endothelial NO synthase (eNOS) expression and NO production in endothelial cells, increasing thus the activity of nuclear factor kappa B (NF-κB) and the pro-oxidant enzyme NOX (Giri et al., 2018). This evidence concerns the gene PRRT2 and Hyperglycemia.