Hyperglycemia can induce vascular endothelial damage through different pathways: (I) enhanced polyol activity, causing sorbitol and fructose accumulation; (II) enhanced production of advanced glycation end products (AGEs); (III) activation of mitogenic protein kinase C (PKC); (IV) heightened hexosamine flux pathway and (V) a decrease of body anti-oxidant defenses (Brownlee, 2001; Kornfeld et al., 2015). Here, PRRT2 is linked to Hyperglycemia.