ACACA and hepatocellular carcinoma: Pu-erh tea inhibited the activity of fatty acid synthase (FASN) and acetyl-coenzyme A carboxylase (ACC), key enzymes for lipogenesis and long-chain FA synthesis, in human hepatoma HepG2 cells and rats fed a high-fructose diet and white adipose tissue of ICR mice (Way et al., 2009; Huang and Lin, 2012; Yamashita et al., 2014).