Hyperglycemia contributes to AGEs formation (reactive intracellular dicarbonyls react with the amino groups of intracellular and extracellular proteins to form AGEs (Brownlee, 2001) which is present in diabetic renal glomeruli according to the literature (Horie et al., 1997) as well as increase xanthine oxidase activity. Here, XDH is linked to Hyperglycemia.