Both astrocytes and microglia clear Aβ (Paresce et al., 1996; Wyss-Coray et al., 2003; Ries and Sastre, 2016) and although there is some evidence that APOE4 may enhance Aβ production (Ye et al., 2005), it is widely thought that APOE4 confers AD risk through deficient Aβ clearance compared to APOE3 and APOE2 (Koistinaho et al., 2004; Deane et al., 2008; Simonovitch et al., 2016), although not necessarily via direct binding (Verghese et al., 2013). The gene discussed is APOE; the disease is Alzheimer disease.