NR3C1 and post-traumatic stress disorder: Further, in a study of mothers with posttraumatic stress disorder (PTSD), lower NR3C1 DNAm in saliva was associated with greater symptom severity and parenting stress; the authors posited that NR3C1 DNAm effect direction could be dependent on how exposures are individually “processed,” reflecting the importance of context (Schechter et al., 2015).