Although the influence of Tau pathology on insulin signaling is not completely understood, it is known that insulin resistance can induce Tau hyperphosphorylation and cognitive decline in human and in animal models (Deng et al., 2009; El Khoury et al., 2014; Yarchoan et al., 2014; Benedict and Grillo, 2018). The gene discussed is MAPT; the disease is Mental deterioration.