In some pathological contexts, such as temporal lobe epilepsy and TBI as well as in another different model of acquired epilepsy, parvalbumin interneurons are known to be very sensitive to death (Drexel et al., 2011; Hsieh et al., 2014) and their loss is involved in the dentate gyrus hyperexcitability triggered by aberrant sprouting (Zhang and Buckmaster, 2009). This evidence concerns the gene PVALB and temporal lobe epilepsy.