We have previously hypothesized about the important role that reelin could play in the neurobiology of depression (Caruncho et al., 2016), as revealed by our observations that depression-like behavior is associated with a significant decrease in the number of reelin+ cells in the subgranular zone (Lussier et al., 2009; Fenton et al., 2015). The gene discussed is RELN; the disease is depressive symptom measurement.