Cp has also been recognized as marker of inflammation in systemic pathologies (Göçmen et al., 2008; Tang et al., 2012) and we found that the Cp:Tf ratio is elevated in Alzheimer’s disease (Squitti et al., 2010; Siotto et al., 2016), in stroke (Altamura et al., 2009; Squitti et al., 2018b) and in subacute post-stroke patients affected by neuropathic pain (Siotto et al., 2017), where it correlates with the clinical status. Here, CP is linked to early-onset autosomal dominant Alzheimer disease.