ACHE and Alzheimer disease: Activity of acetylcholinesterase in central nerve cells was observed a few decades back leading to large research efforts to therapeutically target them for modifications of the cholinergic pathways in AD (Giacobini and Zajicek, 1956; Marchi et al., 1980; De Sarno et al., 1989; Giacobini et al., 1989; Messamore et al., 1993a,b; Zhu and Giacobini, 1995; Giacobini, 1998, 2004; Taylor, 1998).