The ChEIs were developed to halt the activity of the acetylcholine (ACh) degrading enzyme called acetylcholinesterase (AChE), which in turn is part of the cholinergic pathway, and was inherently based on the ‘cholinergic hypotheses’ of AD development (Bartus et al., 1982; Bartus, 2000; Mufson et al., 2008). The gene discussed is ACHE; the disease is Alzheimer disease.