PXR activation by PCN is protective against DSS-induced colitis due to the activation of phase II enzymes and cellular efflux transporters, such as GSTa1, MDR1a, and MRP2, which alleviates the expression of the proinflammatory cytokines IL-6, TNF-α, ΜCP-1, and IL-1β [74]. The gene discussed is TNF; the disease is colitis.