Additionally, production of the type 2 cytokines IL-4, IL-5, IL-9, and IL-13 is related to the severity of IBD [45–47], and neutralization of the central cytokines IL-4 and IL-13 has been shown to control experimental intestinal inflammation owing to the involvement of type 2 responses in proinflammatory pathways at the enteric mucosa. This evidence concerns the gene IL4 and inflammatory bowel disease.