Ezrin, which is the most important member of the ERM family, was primarily expressed in a variety of malignant tissues that originate from epithelial or non-epithelial cells.27 Wang et al. reported that Ezrin is positively related to lymph node metastasis of patients with TSCC, and high activities of Ezrin suggest poor prognosis of these patients,28 which suggested that Ezrin may function as an oncogene. The gene discussed is ETV5; the disease is metastasis.