This finding was similarly to the one of Youn et al., they found that ezrin/calpain/PI3K/AMPK/AKT/eNOSs1179 pathway was critical for VEGF induction of endothelial nitric oxide (NO) production, which would, in turn, mediate VEGF-dependent angiogenesis.41 These findings broadened our understanding that Ezrin-regulated EMT via the AKT pathway, and suggested new strategies for the improvement of cancer therapeutics via the inhibition of AKT-mediated tumour metastasis. This evidence concerns the gene AKT1 and cancer.