PLEK and celiac disease: For instance, for celiac disease, we identified four loci at non HLA-genes including the AS-SNP rs2216763 located in an intron of the RMI2 gene, important for gene stability and linked to celiac disorder32, two AS-SNPs (rs17035374 and rs12468278) located in two regulatory elements associated to the PLEK gene33, the AS-SNP rs6776027 in an intron of the FRMD4B gene, a reported celiac locus34 and the AS-SNP rs10511390, located in an intron of the ARGAP31 gene involved in intestinal barrier function and linked to celiac disorder35.