By contrast, other lymphocyte-related gene sets were most emphasized in SLE, including ‘glucose-6-phosphate isomerase protein-protein interaction (GPI PPI subnetwork, P = 2.08 × 10−5)’, ‘TRAF3 PPI subnetwork (P = 3.82 × 10−5)’ and ‘decreased interleukin-2 secretion (P = 4.57 × 10−5)’. The gene discussed is TRAF3; the disease is systemic lupus erythematosus.