Downregulated genes included THBS1, which is associated with adipocyte proliferation and fatty acid uptake74, C1QTNF3, an adipokine that increases hepatic lipid oxidation and decreases lipid synthesis, gluconeogenesis and inflammation75, and TGFBI, a TGF beta family member associated with type 2 diabetes and adipogenesis76. Here, C1QTNF3 is linked to type 2 diabetes mellitus.