Indeed GLP-1R agonists proved to be efficient for the treatment of type 2 diabetes mellitus37 and studies indicate they could be used in other indications26,43,44 such as obesity45,46, adverse cardiovascular events25, cognitive disorders44 and non-alcoholic steatohepatitis (NASH)47. The gene discussed is GLP1R; the disease is metabolic dysfunction-associated steatohepatitis.