As NLRP3 inflammasome activation is implicated in RA pathophysiology40,45, we measured FADD in the sera from RA-suffering patients of the ESPOIR cohort (Etude et Suivi des Polyarthrites Indifférenciées Récentes)46, a French national multi-centric cohort of patients having early arthritis that started <6 months previously. The gene discussed is NLRP3; the disease is rheumatoid arthritis.