Moreover, BRN2 expression increases as melanomas progress to become invasive, consistent with BRN2 in vivo being expressed specifically in migrating melanoma cells within tumors (Goodall et al. 2008; Pinner et al. 2009) and promoting melanoma invasion in vitro and in vivo (Arozarena et al. 2011; Thurber et al. 2011; Fane et al. 2017; Zeng et al. 2018). The gene discussed is POU3F2; the disease is melanoma.