Although absent or at low levels in melanoblasts and differentiated melanocytes in vivo (Goodall et al. 2004a), BRN2 re-emerges as a critical driver of invasiveness and regulator of proliferation during melanomagenesis (Eisen et al. 1995; Cook and Sturm 2008; Goodall et al. 2008; Besch and Berking 2014; Zeng et al. 2018; Fane et al. 2019), where it is up-regulated by melanoma-associated signaling downstream from BRAF (Goodall et al. 2004b), β-catenin (Goodall et al. 2004a), or PI3K (Bonvin et al. 2012), as well as by E2F1 (Zeng et al. 2018). This evidence concerns the gene BRAF and melanoma.