Intriguingly, BRN2 is overexpressed in tumors with neuroendocrine cell origin such as glioblastoma (Schreiber et al. 1990) and small-cell and carcinoid lung cancer (Ishii et al. 2013) and is a key driver of neuroendocrine prostate cancer proliferation (Bishop et al. 2017). Here, POU3F2 is linked to glioblastoma.