Given the key role played by BRN2 as a tissue-restricted transcription factor expressed in melanoma but not in other cells in the skin (Richmond-Sinclair et al. 2008; Zeng et al. 2018), we aimed here to determine whether in addition to contributing to melanoma progression, BRN2 might also contribute to protecting cells from the consequences of DNA damage. This evidence concerns the gene POU3F2 and melanoma.