In vivo (Goodall et al. 2008) or in 3D culture (Thurber et al. 2011), MITF and BRN2 are expressed in distinct subpopulations of melanoma cells, likely reflecting a feedback loop in which MITF activates miR-211 expression that represses BRN2 to alleviate the suppression of MITF (Boyle et al. 2011). The gene discussed is MITF; the disease is melanoma.