POU3F2 and melanoma: In melanoma, BRN2 is expressed in response to oncogenic signaling downstream from BRAF, β-catenin, or PI3K (Goodall et al. 2004a,b; Bonvin et al. 2012) and is especially recognized as playing a critical role in melanoma invasion (Goodall et al. 2008; Arozarena et al. 2011; Fane et al. 2017; Zeng et al. 2018; Thurber et al. 2011).