The dermatitis in SHARPIN‐deficient cpdm mice is caused by cell or tissue intrinsic defects leading to TNF‐induced cell death of keratinocytes (Kumari et al, 2014; Rickard et al, 2014) and it is not mediated by immune cells as allogeneic BM or splenocyte transplantations fail to transfer the disease to WT mice (HogenEsch et al, 1993; Rickard et al, 2014). Here, SHARPIN is linked to dermatitis.