The deubiquitinase OTULIN removes methionine‐1 (M1)‐linked polyubiquitin signals conjugated by the linear ubiquitin chain assembly complex (LUBAC) and is critical for preventing TNF‐driven inflammation in OTULIN‐related autoinflammatory syndrome (ORAS). The gene discussed is TNF; the disease is autoinflammation, panniculitis, and dermatosis syndrome, autosomal recessive.