SHARPIN‐deficient cpdm (chronic proliferative dermatitis) mice (HogenEsch et al, 1993; Seymour et al, 2007; Gerlach et al, 2011; Ikeda et al, 2011) and patients with mutations in HOIP or HOIL‐1 (Boisson et al, 2012, 2015, 2015) develop severe autoinflammatory syndromes. This evidence concerns the gene SHARPIN and autoinflammatory syndrome.