RNF31 and autoinflammatory syndrome: SHARPIN‐deficient cpdm (chronic proliferative dermatitis) mice (HogenEsch et al, 1993; Seymour et al, 2007; Gerlach et al, 2011; Ikeda et al, 2011) and patients with mutations in HOIP or HOIL‐1 (Boisson et al, 2012, 2015, 2015) develop severe autoinflammatory syndromes.