Mice with genetic ablation of OTULIN either in all haematopoietic cell types or specifically in myeloid cells develop systemic ORAS‐like inflammation, but the organ‐specific symptoms that are hallmarks of the human disease (panniculitis, diarrhoea and arthritis) do not manifest spontaneously in these models (Damgaard et al, 2016). Here, OTULIN is linked to panniculitis.