ICAM1 and malaria: Thus, it is most likely that cerebral malaria‐causing parasites do not adhere specifically to the brain, but rather bind to all EPCR and ICAM‐1 expressing tissues, or even additional other receptors, such as gC1qR, which has been associated with severe malaria and rosetting, but remains to be investigated in the context of cerebral malaria (Mayor et al, 2011).