No associations of genetically predicted serum calcium concentrations with any stroke outcome were observed after exclusion of the SNP in GCKR, which has pleiotropic associations with potential confounders (e.g., blood lipids and type 2 diabetes) (data available from Open Science Framework, table e-8).17 No outliers were identified in the MR-PRESSO analysis. The gene discussed is GCKR; the disease is Stroke.