A main characteristic of cancer development is the loss of coordination in expression between UC and MC genes together with overexpression of UC genes and downregulation of MC genes (Trigos et al., 2017), suggesting a compartmentalization of the GRN into UC and MC gene network regions interconnected by key regulatory links that get disrupted by mutations during cancer development (Trigos et al., 2018) (Figure 3A). This evidence concerns the gene GRN and cancer.