ILK and breast carcinoma: For example, the IC50 of XAV939, an inhibitor of Wnt/β-catenin, was also strongly correlated with the dependency to ILK (−0.30), a regulator of integrin-mediated signal transduction involved in tumor growth and metastasis, supporting the use of Wnt/β-catenin inhibitors for cancers dependent on ILK, including colon, gastric and ovarian and breast cancers (Hannigan et al., 2005).