PTEN and colorectal carcinoma: Moreover, the patterns of methylation and promoter or enhancer histone marks in genes that are often dysregulated in CRC (such as Arid1b, Cdkn2a, Daxx, Gata3, Map3k1, Notch1, Pten, Smad2, Hoxa5, Polg, Runx1, Runx3, CD37, Stx11, Tceb2, Lgr6, Cdx1, and Fut4) and the expression of miRNAs such as miR-375-3p, miR-21, miR-182, and miR-503 have been shown to be modulated by the gut microbiome.