PKD1 and Renal cyst: Recently the Warburg effect metabolic change that is characteristic of cancer has been identified in ADPKD [13].C-Glucose tracking in a kidney specific PKD1-null mouse model found that cystic kidneys had increased aerobic glycolysis, and transcriptomics of human ADPKD kidneys revealed gluconeogenesis enzymes were downregulated while some glycolytic enzymes were upregulated [33].