On the other hand many research articles expressed view that the p16 expression increases progressively with change of histopathological grade such as CIN I has the lowest expression and CIN III has the highest (Tsoumpou et al., 2009; Wu et al., 2014; Von Knebel et al., 2012) which subsequently progress to carcinoma cervix. This evidence concerns the gene CDKN2A and uterine cervix carcinoma in situ.