In recent studies, LGR4 has been shown to promote the proliferation of cancer cells through the activation of the Wnt/β-catenin signalling pathway that plays important roles in stem cell biology, tissue homeostasis and cancer (Carmon et al., 2011; Glinka et al., 2011; Ruffner et al., 2012; Zhu et al., 2013). Here, LGR4 is linked to cancer.