The aim of this study is to evaluate the immunoexpression of LGR4 and β-catenin in primary gastric carcinomas in both histotypes, lymph node metastases and histologically normal gastric mucosa at the tumour resection margins and to correlate the expression of these potential biomarkers with clinical variables such as age, sex and tumour staging. The gene discussed is LGR4; the disease is neoplasm.