The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways are majorly involved in several biological processes such as proliferation, survival, angiogenesis, and metastasis and invasion of CRC cells (Cohen et al., 2005; Fang and Richardson, 2005; Steelman et al., 2011). This evidence concerns the gene PTEN and colorectal carcinoma.